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2015 ; 75
(ä): 120-7
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Selective autophagy: xenophagy
#MMPMID25497060
Bauckman KA
; Owusu-Boaitey N
; Mysorekar IU
Methods
2015[Mar]; 75
(ä): 120-7
PMID25497060
show ga
Xenophagy is an autophagic phenomenon that specifically involves pathogens and
other non-host entities. Although the understanding of the relationship between
autophagosomes and invading organisms has grown significantly in the past decade,
the exact steps to confirm xenophagy has been not been thoroughly defined. Here
we describe a methodical approach to confirming autophagy, its interaction with
bacterial invasion, as well as the specific type of autophagic formation (i.e.
autophagosome, autolysosome, phagolysosome). Further, we argue that xenophagy is
not limited to pathogen interaction with autophagosome, but also non-microbial
entities such as iron.