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10.1038/nchembio.1671 http://scihub22266oqcxt.onion/10.1038/nchembio.1671 C4639395!4639395 !25325686     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25325686 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25325686 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Chem+Biol 2014 ; 10 (11 ): 870-4 Nephropedia Template TP {{tp|p=25325686 |t=2014. Sculpting the proteome with small molecules |pdf=|usr=}}{{25325686 }} gab.com Text Sculpting the proteome with small molecules JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=25325686 #FOAvip The ubiquitin-proteasome system (UPS) pervades the biology of eukaryotes. Because it depends on the activity of hundreds of different enzymes and protein-protein interactions, the UPS provides many opportunities for selective modulation of the pathway with small molecules. Here we discuss the principles that underlie the development of effective inhibitors or activators of the pathway. We emphasize insights from structural analysis and describe strategies for evaluating the selectivity of compounds. Twit Text FOAVip Sculpting the proteome with small molecules ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=25325686 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25325686 #FOAvip English Wikipedia <ref>{{Cite pmid|25325686 }}</ref> Sculpting the proteome with small molecules #MMPMID25325686 King RW ; Finley D Nat Chem Biol 2014[Nov]; 10 (11 ): 870-4 PMID25325686 show ga The ubiquitin-proteasome system (UPS) pervades the biology of eukaryotes. Because it depends on the activity of hundreds of different enzymes and protein-protein interactions, the UPS provides many opportunities for selective modulation of the pathway with small molecules. Here we discuss the principles that underlie the development of effective inhibitors or activators of the pathway. We emphasize insights from structural analysis and describe strategies for evaluating the selectivity of compounds. |Animals [MESH] |Humans [MESH] |Models, Molecular [MESH] |Proteasome Endopeptidase Complex/chemistry/*metabolism [MESH] |Protein Binding/drug effects [MESH] |Proteome/*drug effects/*metabolism [MESH] |Small Molecule Libraries/chemistry/*pharmacology [MESH] |Substrate Specificity/drug effects [MESH] |Ubiquitin-Conjugating Enzymes/chemistry/metabolism [MESH]Sculpting the proteome with small molecules (epmc).pdf DeepDyve Pubget Overpricing