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2015 ; 34
(17
): 2217-8
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Scissors for autolysosome tubules
#MMPMID26224596
Chen Y
; Yu L
EMBO J
2015[Sep]; 34
(17
): 2217-8
PMID26224596
show ga
Autophagic lysosome reformation (ALR) is a cellular process in which lysosomes
are reformed through scission of proto-lysosomes from tubular structures extruded
from autolysosomes. Despite recent progress, the molecular mechanism of ALR is
far from clear. A paper in this issue of The EMBO Journal has identified
lysosome-localized PI(3)P, which is generated by the VPS34?UVRAG complex in an
mTOR-dependent manner, as an important regulator of autolysosome tubule scission
(Munson et al, 2015).
|Animals
[MESH]
|Class III Phosphatidylinositol 3-Kinases/*metabolism
[MESH]