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10.15252/embj.201592519

http://scihub22266oqcxt.onion/10.15252/embj.201592519
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C4585459!4585459 !26224596
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suck abstract from ncbi


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pmid26224596
      EMBO+J 2015 ; 34 (17 ): 2217-8
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  • Scissors for autolysosome tubules #MMPMID26224596
  • Chen Y ; Yu L
  • EMBO J 2015[Sep]; 34 (17 ): 2217-8 PMID26224596 show ga
  • Autophagic lysosome reformation (ALR) is a cellular process in which lysosomes are reformed through scission of proto-lysosomes from tubular structures extruded from autolysosomes. Despite recent progress, the molecular mechanism of ALR is far from clear. A paper in this issue of The EMBO Journal has identified lysosome-localized PI(3)P, which is generated by the VPS34?UVRAG complex in an mTOR-dependent manner, as an important regulator of autolysosome tubule scission (Munson et al, 2015).
  • |Animals [MESH]
  • |Class III Phosphatidylinositol 3-Kinases/*metabolism [MESH]
  • |Humans [MESH]
  • |Lysosomes/*metabolism [MESH]
  • |TOR Serine-Threonine Kinases/*metabolism [MESH]


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