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2016 ; 388
(10039
): 86-97
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Schizophrenia
#MMPMID26777917
Owen MJ
; Sawa A
; Mortensen PB
Lancet
2016[Jul]; 388
(10039
): 86-97
PMID26777917
show ga
Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that
seems to originate from disruption of brain development caused by genetic or
environmental factors, or both. Dysfunction of dopaminergic neurotransmission
contributes to the genesis of psychotic symptoms, but evidence also points to a
widespread and variable involvement of other brain areas and circuits.
Disturbances of synaptic function might underlie abnormalities of neuronal
connectivity that possibly involves interneurons, but the precise nature,
location, and timing of these events are uncertain. At present, treatment mainly
consists of antipsychotic drugs combined with psychological therapies, social
support, and rehabilitation, but a pressing need for more effective treatments
and delivery of services exists. Advances in genomics, epidemiology, and
neuroscience have led to great progress in understanding the disorder, and the
opportunities for further scientific breakthrough are numerous--but so are the
challenges.
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