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10.1007/s00441-014-2088-1 http://scihub22266oqcxt.onion/10.1007/s00441-014-2088-1 C4414737!4414737 !25616555     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25616555 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25616555 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Tissue+Res 2015 ; 360 (2 ): 321-32 Nephropedia Template TP {{tp|p=25616555 |t=2015. Scaffolding protein GOPC regulates tight junction structure |pdf=|usr=}}{{25616555 }} gab.com Text Scaffolding protein GOPC regulates tight junction structure JO: Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=25616555 #FOAvip GOPC (FIG/PIST/CAL) is a PDZ-domain scaffolding protein that regulates the trafficking of a wide array of proteins, including small GTPases, receptors and cell surface molecules such as cadherin 23 and cystic fibrosis transmembrane regulator. In Madin-Darby canine kidney (MDCK) cells, we find that GOPC localizes to the trans-Golgi network (TGN) but not to the cis- or trans-Golgi cisternae. Colocalization occurs with the early endosome Rab GTPase Rab5 and a TGN/endosome marker Rab14 but not with Rab11, a marker of recycling endosomes. No localization of GOPC was detected to the lateral membranes or tight junctions. Knockdown of GOPC in MDCK cells results in decreased transepithelial resistance and increased paracellular flux. This might be attributable to the compromised trafficking of tight junction components from the TGN, as GOPC-knockdown cells have decreased lateral labeling of the tight junction protein claudin-1 and decreased protein levels of claudin-2. GOPC might mediate the trafficking of newly synthesized tight junction proteins from the TGN to the cell surface or the recycling of these proteins from specialized endosomal compartments. Twit Text FOAVip Scaffolding protein GOPC regulates tight junction structure ????Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=25616555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25616555 #FOAvip English Wikipedia <ref>{{Cite pmid|25616555 }}</ref> Scaffolding protein GOPC regulates tight junction structure #MMPMID25616555 Lu R ; Stewart L ; Wilson JM Cell Tissue Res 2015[May]; 360 (2 ): 321-32 PMID25616555 show ga GOPC (FIG/PIST/CAL) is a PDZ-domain scaffolding protein that regulates the trafficking of a wide array of proteins, including small GTPases, receptors and cell surface molecules such as cadherin 23 and cystic fibrosis transmembrane regulator. In Madin-Darby canine kidney (MDCK) cells, we find that GOPC localizes to the trans-Golgi network (TGN) but not to the cis- or trans-Golgi cisternae. Colocalization occurs with the early endosome Rab GTPase Rab5 and a TGN/endosome marker Rab14 but not with Rab11, a marker of recycling endosomes. No localization of GOPC was detected to the lateral membranes or tight junctions. Knockdown of GOPC in MDCK cells results in decreased transepithelial resistance and increased paracellular flux. This might be attributable to the compromised trafficking of tight junction components from the TGN, as GOPC-knockdown cells have decreased lateral labeling of the tight junction protein claudin-1 and decreased protein levels of claudin-2. GOPC might mediate the trafficking of newly synthesized tight junction proteins from the TGN to the cell surface or the recycling of these proteins from specialized endosomal compartments. |Animals [MESH] |Carrier Proteins/genetics/*metabolism [MESH] |Dogs [MESH] |Endosomes/genetics/metabolism [MESH] |Madin Darby Canine Kidney Cells [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Protein Transport/physiology [MESH] |Tight Junctions/genetics/*metabolism [MESH] |rab5 GTP-Binding Proteins/genetics/metabolism [MESH]Scaffolding protein GOPC regulates tight junction structure (epmc).pdf DeepDyve Pubget Overpricing