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2013 ; 2013
(ä): 928601
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Sarcoidosis: Immunopathogenesis and Immunological Markers
#MMPMID26464848
Loke WS
; Herbert C
; Thomas PS
Int J Chronic Dis
2013[]; 2013
(ä): 928601
PMID26464848
show ga
Sarcoidosis is a multisystem granulomatous disorder invariably affecting the
lungs. It is a disease with noteworthy variations in clinical manifestation and
disease outcome and has been described as an "immune paradox" with peripheral
anergy despite exaggerated inflammation at disease sites. Despite extensive
research, sarcoidosis remains a disease with undetermined aetiology. Current
evidence supports the notion that the immune response in sarcoidosis is driven by
a putative antigen in a genetically susceptible individual. Unfortunately, there
currently exists no reliable biomarker to delineate the disease severity and
prognosis. As such, the diagnosis of sarcoidosis remains a vexing clinical
challenge. In this review, we outline the immunological features of sarcoidosis,
discuss the evidence for and against various candidate etiological agents
(infective and noninfective), describe the exhaled breath condensate, a novel
method of identifying immunological biomarkers, and suggest other possible
immunological biomarkers to better characterise the immunopathogenesis of
sarcoidosis.