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2014 ; 5
(10
): 1129-32
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Saralasin and Sarile Are AT2 Receptor Agonists
#MMPMID25313325
Guimond MO
; Hallberg M
; Gallo-Payet N
; Wallinder C
ACS Med Chem Lett
2014[Oct]; 5
(10
): 1129-32
PMID25313325
show ga
Saralasin and sarile, extensively studied over the past 40 years as angiotensin
II (Ang II) receptor blockers, induce neurite outgrowth in a NG108-15 cell assay
to a similar extent as the endogenous Ang II. In their undifferentiated state,
these cells express mainly the AT2 receptor. The neurite outgrowth was inhibited
by preincubation with the AT2 receptor selective antagonist PD 123,319, which
suggests that the observed outgrowth was mediated by the AT2 receptor. Neither
saralasin nor sarile reduced the neurite outgrowth induced by Ang II proving that
the two octapeptides do not act as antagonists at the AT2 receptor and may be
considered as AT2 receptor agonists.