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2018 ; 1414
(1
): 59-71
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Safety of folic acid
#MMPMID29155442
Field MS
; Stover PJ
Ann N Y Acad Sci
2018[Feb]; 1414
(1
): 59-71
PMID29155442
show ga
There is a large body of literature demonstrating the efficacy of maternal folic
acid intake in preventing birth defects, as well as investigations into potential
adverse consequences of consuming folic acid above the upper intake level (UL).
Recently, two authoritative bodies convened expert panels to assess risks from
high intakes of folic acid: the U.S. National Toxicology Program and the UK
Scientific Advisory Committee on Nutrition. Overall, the totality of the evidence
examined by these panels, as well as studies published since the release of their
reports, have not established risks for adverse consequences resulting from
existing mandatory folic acid fortification programs that have been implemented
in many countries. Current folic acid fortification programs have been shown to
support public health in populations, and the exposure levels are informed by and
adherent to the precautionary principle. Additional research is needed to assess
the health effects of folic acid supplement use when the current upper limit for
folic acid is exceeded.
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