Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24440645
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Immunol
2014 ; 150
(2
): 201-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
SLAP deficiency decreases dsDNA autoantibody production
#MMPMID24440645
Peterson LK
; Pennington LF
; Shaw LA
; Brown M
; Treacy EC
; Friend SF
; Hatlevik Ø
; Rubtsova K
; Rubtsov AV
; Dragone LL
Clin Immunol
2014[Feb]; 150
(2
): 201-9
PMID24440645
show ga
Src-like adaptor protein (SLAP) adapts c-Cbl, an E3 ubiquitin ligase, to
activated components of the BCR signaling complex regulating BCR levels and
signaling in developing B cells. Based on this function, we asked whether SLAP
deficiency could decrease the threshold for tolerance and eliminate development
of autoreactive B cells in two models of autoantibody production. First, we
sensitized mice with a dsDNA mimetope that causes an anti-dsDNA response. Despite
equivalent production of anti-peptide antibodies compared to BALB/c controls,
SLAP(-/-) mice did not produce anti-dsDNA. Second, we used the 56R tolerance
model. SLAP(-/-) 56R mice had decreased levels of dsDNA-reactive antibodies
compared to 56R mice due to skewed light chain usage. Thus, SLAP is a critical
regulator of B-cell development and function and its deficiency leads to
decreased autoreactive B cells that are otherwise maintained by inefficient
receptor editing or failed negative selection.
free
free
free
