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10.1042/BCJ20170945 http://scihub22266oqcxt.onion/10.1042/BCJ20170945 C6024822!6024822 !29784889     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29784889 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29784889 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochem+J 2018 ; 475 (12 ): 2073-2090 Nephropedia Template TP {{tp|p=29784889 |t=2018. SINHCAF/FAM60A and SIN3A specifically repress HIF-2? expression |pdf=|usr=}}{{29784889 }} gab.com Text SINHCAF/FAM60A and SIN3A specifically repress HIF-2 expression JO: Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=29784889 #FOAvip The SIN3A-HDAC (histone deacetylase) complex is a master transcriptional repressor, required for development but often deregulated in disease. Here, we report that the recently identified new component of this complex, SINHCAF (SIN3A and HDAC-associated factor)/FAM60A (family of homology 60A), links the SIN3A-HDAC co-repressor complex function to the hypoxia response. We show that SINHCAF specifically represses HIF-2? mRNA and protein expression, via its interaction with the transcription factor SP1 (specificity protein 1) and recruitment of HDAC1 to the HIF-2? promoter. SINHCAF control over HIF-2? results in functional cellular changes in in vitro angiogenesis and viability. Our analysis reveals an unexpected link between SINHCAF and the regulation of the hypoxia response. Twit Text FOAVip SINHCAF/FAM60A and SIN3A specifically repress HIF-2 expression ????Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=29784889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29784889 #FOAvip English Wikipedia <ref>{{Cite pmid|29784889 }}</ref> SINHCAF/FAM60A and SIN3A specifically repress HIF-2? expression #MMPMID29784889 Biddlestone J ; Batie M ; Bandarra D ; Munoz I ; Rocha S Biochem J 2018[Jun]; 475 (12 ): 2073-2090 PMID29784889 show ga The SIN3A-HDAC (histone deacetylase) complex is a master transcriptional repressor, required for development but often deregulated in disease. Here, we report that the recently identified new component of this complex, SINHCAF (SIN3A and HDAC-associated factor)/FAM60A (family of homology 60A), links the SIN3A-HDAC co-repressor complex function to the hypoxia response. We show that SINHCAF specifically represses HIF-2? mRNA and protein expression, via its interaction with the transcription factor SP1 (specificity protein 1) and recruitment of HDAC1 to the HIF-2? promoter. SINHCAF control over HIF-2? results in functional cellular changes in in vitro angiogenesis and viability. Our analysis reveals an unexpected link between SINHCAF and the regulation of the hypoxia response. |*Gene Expression Regulation [MESH] |A549 Cells [MESH] |Basic Helix-Loop-Helix Transcription Factors/*biosynthesis/genetics [MESH] |DNA-Binding Proteins/genetics/*metabolism [MESH] |HeLa Cells [MESH] |Histone Deacetylase 1/genetics/metabolism [MESH] |Humans [MESH] |Promoter Regions, Genetic [MESH] |RNA, Messenger/*biosynthesis/genetics [MESH] |Repressor Proteins/genetics/*metabolism [MESH]SINHCAF/FAM60A and SIN3A specifically repress HIF-2? expression (epmc).pdf DeepDyve Pubget Overpricing