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10.1007/s12551-012-0081-z

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suck abstract from ncbi


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pmid28510178
      Biophys+Rev 2013 ; 5 (1 ): 29-39
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  • SH3 domains: modules of protein-protein interactions #MMPMID28510178
  • Kurochkina N ; Guha U
  • Biophys Rev 2013[Mar]; 5 (1 ): 29-39 PMID28510178 show ga
  • Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a number of noncanonical sequences by SH3 domains has been extensively studied by crystallography, nuclear magnetic resonance and other methods. High-affinity peptides that bind SH3 domains are used in drug development as candidates for anticancer treatment. This review summarizes the latest achievements in deciphering structural determinants of SH3 function.
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