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10.18632/oncotarget.20837 http://scihub22266oqcxt.onion/10.18632/oncotarget.20837 C5689660!5689660 !29156770     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29156770 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (49 ): 85969-85983 Nephropedia Template TP {{tp|p=29156770 |t=2017. SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma |pdf=|usr=}}{{29156770 }} gab.com Text SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29156770 #FOAvip Angiogenesis plays a critical role in glioblastoma growth and progression. We therefore aimed at evaluating the anti-angiogenic properties of an oligopeptide originating from SCO-spondin (NX) on a model of human glioblastoma. To this end, we studied the impact of NX treatment on human brain endothelial cells (HBMECs) alone or co-cultured with glioblastoma cells (U87-MG) on apoptosis, proliferation, migration and release of angiogenic factors. We further investigated the anti-angiogenic potential of NX on human glioblastoma cells grown on chorio-allantoic membrane (CAM) or in glioblastoma xenografts. The results of our experiments showed that NX treatment impaired the microvascular network and induced a decrease in cell proliferation, vascularization and tumor growth in the CAM model as well as in xenotransplants. Interestingly, our in vitro experiments showed that NX impairs HBMECs migration but also regulates the release of angiogenic factors from U87-MG. These results are confirmed by the profiling of NX-treated U87-MG grown on CAM that highlighted modifications of several genes involved in angiogenesis. In conclusion, NX inhibits tumorigenesis by impairing the ability of glioblastoma cells to induce angiogenesis and by inhibiting endothelial cell migration. This molecule might therefore be an interesting candidate for future cancer therapies. Twit Text FOAVip SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29156770 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29156770 #FOAvip English Wikipedia <ref>{{Cite pmid|29156770 }}</ref> SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma #MMPMID29156770 Bibes R ; Gobron S ; Vincent F ; Mélin C ; Vedrenne N ; Perraud A ; Labrousse F ; Jauberteau MO ; Lalloué F Oncotarget 2017[Oct]; 8 (49 ): 85969-85983 PMID29156770 show ga Angiogenesis plays a critical role in glioblastoma growth and progression. We therefore aimed at evaluating the anti-angiogenic properties of an oligopeptide originating from SCO-spondin (NX) on a model of human glioblastoma. To this end, we studied the impact of NX treatment on human brain endothelial cells (HBMECs) alone or co-cultured with glioblastoma cells (U87-MG) on apoptosis, proliferation, migration and release of angiogenic factors. We further investigated the anti-angiogenic potential of NX on human glioblastoma cells grown on chorio-allantoic membrane (CAM) or in glioblastoma xenografts. The results of our experiments showed that NX treatment impaired the microvascular network and induced a decrease in cell proliferation, vascularization and tumor growth in the CAM model as well as in xenotransplants. Interestingly, our in vitro experiments showed that NX impairs HBMECs migration but also regulates the release of angiogenic factors from U87-MG. These results are confirmed by the profiling of NX-treated U87-MG grown on CAM that highlighted modifications of several genes involved in angiogenesis. In conclusion, NX inhibits tumorigenesis by impairing the ability of glioblastoma cells to induce angiogenesis and by inhibiting endothelial cell migration. This molecule might therefore be an interesting candidate for future cancer therapies. äSCO-spondin oligopeptide inhibits angiogenesis in glioblastoma (epmc).pdf DeepDyve Pubget Overpricing