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10.1038/nmeth.4463

http://scihub22266oqcxt.onion/10.1038/nmeth.4463
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suck abstract from ncbi


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pmid28991892
      Nat+Methods 2017 ; 14 (11 ): 1083-1086
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  • SCENIC: single-cell regulatory network inference and clustering #MMPMID28991892
  • Aibar S ; González-Blas CB ; Moerman T ; Huynh-Thu VA ; Imrichova H ; Hulselmans G ; Rambow F ; Marine JC ; Geurts P ; Aerts J ; van den Oord J ; Atak ZK ; Wouters J ; Aerts S
  • Nat Methods 2017[Nov]; 14 (11 ): 1083-1086 PMID28991892 show ga
  • We present SCENIC, a computational method for simultaneous gene regulatory network reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic.aertslab.org). On a compendium of single-cell data from tumors and brain, we demonstrate that cis-regulatory analysis can be exploited to guide the identification of transcription factors and cell states. SCENIC provides critical biological insights into the mechanisms driving cellular heterogeneity.
  • |*Gene Regulatory Networks [MESH]
  • |*Single-Cell Analysis [MESH]
  • |Algorithms [MESH]
  • |Animals [MESH]
  • |Brain/metabolism [MESH]
  • |Cluster Analysis [MESH]
  • |Gene Expression Profiling [MESH]
  • |Humans [MESH]


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