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2008 ; 133
(1
): 113-21
Nephropedia Template TP
Virus Res
2008[Apr]; 133
(1
): 113-21
PMID18045721
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The emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV) has
led to a renewed interest in studying the role of accessory proteins in
regulating coronavirus infections in the natural host. A significant body of
evidence has accumulated in the area of SARS-CoV and host interactions that
indicate that the accessory proteins might play an important role in modulating
the host response to virus infection and thereby, contribute to pathogenesis. In
this review, we have compiled the current knowledge about SARS-CoV accessory
proteins, obtained from studies in cell culture systems, reverse genetics and
animal models, to shed some light into the possible role of these proteins in the
propagation and virulence of SARS-CoV in its natural host. We conclude by
providing some questions for future studies that will greatly advance our
knowledge about the biological significance and contributions of the accessory
proteins in the development of SARS in humans.
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