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2015 ; 59
(1
): 5-10
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Rotifers as experimental tools for investigating aging
#MMPMID25642019
Snell TW
; Johnston RK
; Gribble KE
; Mark Welch DB
Invertebr Reprod Dev
2015[Jan]; 59
(1
): 5-10
PMID25642019
show ga
Comparative biogerontology has much to contribute to the study of aging. A broad
range of aging rates has evolved to meet environmental challenges, and
understanding these adaptations can produce valuable insights into aging. The
supra Phylum Lophotrochozoa is particularly understudied and has several groups
that have intriguing patterns of aging. Members of the lophotrochozoan phylum
Rotifera are particularly useful for aging studies because cohort life tables can
be conducted with them easily, and biochemical and genomic tools are available
for examining aging mechanisms. This paper reviews a variety of caloric
restriction regimens, small molecule inhibitors, and dietary supplements that
extend rotifer lifespan, as well as important interactions between caloric
restriction and genotype, antioxidant supplements, and TOR and JNK pathways, and
the use of RNAi to identify key genes involved in modulating the aging response.
Examples of how rapamycin and JNK inhibitor exposure keeps mortality rates low
during the reproductive phase of the life cycle are presented, and the ease of
conducting life table experiments to screen natural products from red algae for
life extending effects is illustrated. Finally, experimental evolution to produce
longer-lived rotifer individuals is demonstrated, and future directions to
determine the genetic basis of aging are discussed.
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