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10.1038/gene.2015.58 http://scihub22266oqcxt.onion/10.1038/gene.2015.58 C4777649!4777649!26673963     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26673963&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26673963.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Immun 2016 ; 17 (2): 79-84 Nephropedia Template TP {{tp|p=26673963|t=2016. Roquin ? a multifunctional regulator of immune homeostasis |pdf=|usr=}}{{26673963}} gab.com Text Roquin a multifunctional regulator of immune homeostasis JO: Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=26673963 #FOAvip Roquin-1 (Rc3h1) is an E3 ubiquitin ligase originally discovered in a mutational screen for genetic factors contributory to systemic lupus erythematosus-like symptoms in mice. A single base pair mutation in the Rc3h1 gene resulted in the manifestation of autoantibody production and sustained immunological inflammation characterized by excessive T follicular helper cell activation and formation of germinal centers. Subsequent studies have uncovered a multifactorial process by which Roquin-1 contributes to the maintenance of immune homeostasis. Through its interactions with partner proteins, Roquin-1 targets mRNAs for decay with inducible costimulator being a primary target. In this review, we discuss newly discovered functions of Roquin-1 in the immune system and inflammation, and in disease manifestation, and discuss avenues of further research. A model is presented for the role of Roquin in health and disease. Twit Text FOAVip Roquin a multifunctional regulator of immune homeostasis ????Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=26673963 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26673963 #FOAvip English Wikipedia <ref>{{Cite pmid|26673963}}</ref> Roquin ? a multifunctional regulator of immune homeostasis #MMPMID26673963 Schaefer JS; Klein JR Genes Immun 2016[Mar]; 17 (2): 79-84 PMID26673963show ga Roquin-1 (Rc3h1) is an E3 ubiquitin ligase originally discovered in a mutational screen for genetic factors contributory to systemic lupus erythematosus-like symptoms in mice. A single base pair mutation in the Rc3h1 gene resulted in the manifestation of autoantibody production and sustained immunological inflammation characterized by excessive T follicular helper cell activation and formation of germinal centers. Subsequent studies have uncovered a multifactorial process by which Roquin-1 contributes to the maintenance of immune homeostasis. Through its interactions with partner proteins, Roquin-1 targets mRNAs for decay with inducible costimulator being a primary target. In this review, we discuss newly discovered functions of Roquin-1 in the immune system and inflammation, and in disease manifestation, and discuss avenues of further research. A model is presented for the role of Roquin in health and disease. äRoquin ? a multifunctional regulator of immune homeostasis (epmc).pdf DeepDyve Pubget Overpricing