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2016 ; 2016
(ä): 6762343
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Roles of Zinc Signaling in the Immune System
#MMPMID27872866
Hojyo S
; Fukada T
J Immunol Res
2016[]; 2016
(ä): 6762343
PMID27872866
show ga
Zinc (Zn) is an essential micronutrient for basic cell activities such as cell
growth, differentiation, and survival. Zn deficiency depresses both innate and
adaptive immune responses. However, the precise physiological mechanisms of the
Zn-mediated regulation of the immune system have been largely unclear. Zn
homeostasis is tightly controlled by the coordinated activity of Zn transporters
and metallothioneins, which regulate the transport, distribution, and storage of
Zn. There is growing evidence that Zn behaves like a signaling molecule,
facilitating the transduction of a variety of signaling cascades in response to
extracellular stimuli. In this review, we highlight the emerging functional roles
of Zn and Zn transporters in immunity, focusing on how crosstalk between Zn and
immune-related signaling guides the normal development and function of immune
cells.