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Role of tumor microenvironment in tumorigenesis
#MMPMID28382138
Wang M
; Zhao J
; Zhang L
; Wei F
; Lian Y
; Wu Y
; Gong Z
; Zhang S
; Zhou J
; Cao K
; Li X
; Xiong W
; Li G
; Zeng Z
; Guo C
J Cancer
2017[]; 8
(5
): 761-773
PMID28382138
show ga
Tumorigenesis is a complex and dynamic process, consisting of three stages:
initiation, progression, and metastasis. Tumors are encircled by extracellular
matrix (ECM) and stromal cells, and the physiological state of the tumor
microenvironment (TME) is closely connected to every step of tumorigenesis.
Evidence suggests that the vital components of the TME are fibroblasts and
myofibroblasts, neuroendocrine cells, adipose cells, immune and inflammatory
cells, the blood and lymphatic vascular networks, and ECM. This manuscript, based
on the current studies of the TME, offers a more comprehensive overview of the
primary functions of each component of the TME in cancer initiation, progression,
and invasion. The manuscript also includes primary therapeutic targeting markers
for each player, which may be helpful in treating tumors.
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