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Role of tumor microenvironment in ovarian cancer pathobiology
#MMPMID29854318
Ghoneum A
; Afify H
; Salih Z
; Kelly M
; Said N
Oncotarget
2018[Apr]; 9
(32
): 22832-22849
PMID29854318
show ga
Ovarian cancer is the fifth most common cancer affecting the female population
and at present, stands as the most lethal gynecologic malignancy. Poor prognosis
and low five-year survival rate are attributed to nonspecific symptoms and below
par diagnostic criteria at early phases along with a lack of effective treatment
at advanced stages. It is thus of utmost importance to understand ovarian
carcinoma through several lenses including its molecular pathogenesis,
epidemiology, histological subtypes, hereditary factors, diagnostic approaches
and methods of treatment. Above all, it is crucial to dissect the role that the
unique peritoneal tumor microenvironment plays in ovarian cancer progression and
metastasis. This review seeks to highlight several important aspects of ovarian
cancer pathobiology as a means to provide the necessary background to approach
ovarian malignancies in the future.
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