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2018 ; 11
(1
): 1-11
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Role of the Nervous System in Tumor Angiogenesis
#MMPMID29502307
Kuol N
; Stojanovska L
; Apostolopoulos V
; Nurgali K
Cancer Microenviron
2018[Jun]; 11
(1
): 1-11
PMID29502307
show ga
The development of cancer involves an intricate process, wherein many identified
and unidentified factors play a role. Tumor angiogenesis, growth of new blood
vessels, is one of the major prerequisites for tumor growth as tumor cells rely
on adequate oxygen and nutrient supply as well as the removal of waste products.
Growth factors including VEGF orchestrate the development of angiogenesis. In
addition, nervous system via the release of neurotransmitters contributes to
tumor angiogenesis. The nervous system governs functional activities of many
organs, and, as tumors are not independent organs within an organism, this system
is integrally involved in tumor growth and progression via regulating tumor
angiogenesis. Various neurotransmitters have been reported to play an important
role in tumor angiogenesis.