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2018 ; 11
(ä): 2063-2073
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Role of the NF?B-signaling pathway in cancer
#MMPMID29695914
Xia L
; Tan S
; Zhou Y
; Lin J
; Wang H
; Oyang L
; Tian Y
; Liu L
; Su M
; Wang H
; Cao D
; Liao Q
Onco Targets Ther
2018[]; 11
(ä): 2063-2073
PMID29695914
show ga
Cancer is a group of cells that malignantly grow and proliferate uncontrollably.
At present, treatment modes for cancer mainly comprise surgery, chemotherapy,
radiotherapy, molecularly targeted therapy, gene therapy, and immunotherapy.
However, the curative effects of these treatments have been limited thus far by
specific characteristics of tumors. Abnormal activation of signaling pathways is
involved in tumor pathogenesis and plays critical roles in growth, progression,
and relapse of cancers. Targeted therapies against effectors in oncogenic
signaling have improved the outcomes of cancer patients. NF?B is an important
signaling pathway involved in pathogenesis and treatment of cancers. Excessive
activation of the NF?B-signaling pathway has been documented in various tumor
tissues, and studies on this signaling pathway for targeted cancer therapy have
become a hot topic. In this review, we update current understanding of the
NF?B-signaling pathway in cancer.