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10.2147/OTT.S161109

http://scihub22266oqcxt.onion/10.2147/OTT.S161109
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suck abstract from ncbi


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pmid29695914
      Onco+Targets+Ther 2018 ; 11 (ä): 2063-2073
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  • Role of the NF?B-signaling pathway in cancer #MMPMID29695914
  • Xia L ; Tan S ; Zhou Y ; Lin J ; Wang H ; Oyang L ; Tian Y ; Liu L ; Su M ; Wang H ; Cao D ; Liao Q
  • Onco Targets Ther 2018[]; 11 (ä): 2063-2073 PMID29695914 show ga
  • Cancer is a group of cells that malignantly grow and proliferate uncontrollably. At present, treatment modes for cancer mainly comprise surgery, chemotherapy, radiotherapy, molecularly targeted therapy, gene therapy, and immunotherapy. However, the curative effects of these treatments have been limited thus far by specific characteristics of tumors. Abnormal activation of signaling pathways is involved in tumor pathogenesis and plays critical roles in growth, progression, and relapse of cancers. Targeted therapies against effectors in oncogenic signaling have improved the outcomes of cancer patients. NF?B is an important signaling pathway involved in pathogenesis and treatment of cancers. Excessive activation of the NF?B-signaling pathway has been documented in various tumor tissues, and studies on this signaling pathway for targeted cancer therapy have become a hot topic. In this review, we update current understanding of the NF?B-signaling pathway in cancer.
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