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10.1002/jnr.23749 http://scihub22266oqcxt.onion/10.1002/jnr.23749 C5074285!5074285!27112131     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27112131.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Neurosci+Res 2016 ; 94 (8): 693-701 Nephropedia Template TP {{tp|p=27112131|t=2016. Role of regulatory b cells in neuroimmunologic disorders |pdf=|usr=}}{{27112131}} gab.com Text Role of regulatory b cells in neuroimmunologic disorders JO: J Neurosci Res http://www.kidney.de/pget.php?&tw=1&pmid=27112131 #FOAvip B lymphocytes augment the immune response by producing antibodies and activating T cells by antigen presentation. Recent studies have highlighted a specific and functionally significant B?cell subset that could downregulate excessive immune and inflammatory responses through a vast array of inhibitory cytokines, such as interleukin (IL)?10 and transforming growth factor?? (TGF??). This subset of B cells is generally referred to as regulatory B cells (Bregs). In addition, recent studies have shown that IL?35?producing Bregs also play a role in downregulation of immunity. Diverse phenotypes of Bregs have been proposed to underlie human disorders and their animal models. Most studies have focused on the role of different subsets of Bregs and Bregs?associated molecules such as IL?10, TGF??, and IL?35 in the pathogenesis of neuroimmunologic disorders. Furthermore, Bregs exert regulatory function mainly through suppressing the differentiation of Th1/Th17 cells and promoting regulatory T?cell expansion. Reduced presence of Bregs is reportedly associated with progression of several neuroimmunologic disorders. This Review summarizes the current knowledge on the role of Bregs in neuroimmunologic disorders, including multiple sclerosis, neuromyelitis optica, and myasthenia gravis. © 2016 The Authors. Journal of Neuroscience Research Published by Wiley Periodicals, Inc. Twit Text FOAVip Role of regulatory b cells in neuroimmunologic disorders ????J Neurosci Res http://www.kidney.de/pget.php?&tw=1&pmid=27112131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27112131 #FOAvip English Wikipedia <ref>{{Cite pmid|27112131}}</ref> Role of regulatory b cells in neuroimmunologic disorders #MMPMID27112131 Han J; Sun L; Fan X; Wang Z; Cheng Y; Zhu J; Jin T J Neurosci Res 2016[Aug]; 94 (8): 693-701 PMID27112131show ga B lymphocytes augment the immune response by producing antibodies and activating T cells by antigen presentation. Recent studies have highlighted a specific and functionally significant B?cell subset that could downregulate excessive immune and inflammatory responses through a vast array of inhibitory cytokines, such as interleukin (IL)?10 and transforming growth factor?? (TGF??). This subset of B cells is generally referred to as regulatory B cells (Bregs). In addition, recent studies have shown that IL?35?producing Bregs also play a role in downregulation of immunity. Diverse phenotypes of Bregs have been proposed to underlie human disorders and their animal models. Most studies have focused on the role of different subsets of Bregs and Bregs?associated molecules such as IL?10, TGF??, and IL?35 in the pathogenesis of neuroimmunologic disorders. Furthermore, Bregs exert regulatory function mainly through suppressing the differentiation of Th1/Th17 cells and promoting regulatory T?cell expansion. Reduced presence of Bregs is reportedly associated with progression of several neuroimmunologic disorders. This Review summarizes the current knowledge on the role of Bregs in neuroimmunologic disorders, including multiple sclerosis, neuromyelitis optica, and myasthenia gravis. © 2016 The Authors. Journal of Neuroscience Research Published by Wiley Periodicals, Inc. äRole of regulatory b cells in neuroimmunologic disorders (epmc).pdf DeepDyve Pubget Overpricing