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2014 ; 8
(4
): 407-13
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Role of osteocytes in multiple myeloma bone disease
#MMPMID25289928
Delgado-Calle J
; Bellido T
; Roodman GD
Curr Opin Support Palliat Care
2014[Dec]; 8
(4
): 407-13
PMID25289928
show ga
PURPOSE OF REVIEW: Despite the increased knowledge of osteocyte biology, the
contribution of this most abundant bone cell to the development and progression
of multiple myeloma in bone is practically unexplored. RECENT FINDINGS: Multiple
myeloma bone disease is characterized by exacerbated bone resorption and the
presence of osteolytic lesions that do not heal because of a concomitant
reduction in bone formation. Osteocytes produce molecules that regulate both bone
formation and resorption. Recent findings suggest that the life span of
osteocytes is compromised in multiple myeloma patients with bone lesions. In
addition, multiple myeloma cells affect the transcriptional profile of osteocytes
by upregulating the production of pro-osteoclastogenic cytokines, stimulating
osteoclast formation and activity. Further, patients with active multiple myeloma
have elevated circulating levels of sclerostin, a potent inhibitor of bone
formation which is specifically expressed by osteocytes in bone. SUMMARY:
Understanding the contribution of osteocytes to the mechanisms underlying the
skeletal consequences of multiple myeloma bone disease has the potential to
provide important new therapeutic strategies that specifically target multiple
myeloma-osteocyte interactions.
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