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2017 ; 14
(4
): 3883-3892
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Role of liver ICAM-1 in metastasis
#MMPMID28943897
Benedicto A
; Romayor I
; Arteta B
Oncol Lett
2017[Oct]; 14
(4
): 3883-3892
PMID28943897
show ga
Intercellular adhesion molecule (ICAM)-1, is a transmembrane glycoprotein of the
immunoglobulin (Ig)-like superfamily, consisting of five extracellular Ig-like
domains, a transmembrane domain and a short cytoplasmic tail. ICAM-1 is expressed
in various cell types, including endothelial cells and leukocytes, and is
involved in several physiological processes. Furthermore, it has additionally
been reported to be expressed in various cancer cells, including melanoma,
colorectal cancer and lymphoma. The majority of studies to date have focused on
the expression of the ICAM-1 on the surface of tumor cells, without research into
ICAM-1 expression at sites of metastasis. Cancer cells frequently metastasize to
the liver, due to its unique physiology and specialized liver sinusoid capillary
network. Liver sinusoidal endothelial cells constitutively express ICAM-1, which
is upregulated under inflammatory conditions. Furthermore, liver ICAM-1 may be
important during the development of liver metastasis. Therefore, it is necessary
to improve the understanding of the mechanisms mediated by this adhesion molecule
in order to develop host-directed anticancer therapies.
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