Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26593723
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Mol+Cell+Cardiol
2016 ; 93
(ä): 143-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Role of inflammatory cells in fibroblast activation
#MMPMID26593723
Hartupee J
; Mann DL
J Mol Cell Cardiol
2016[Apr]; 93
(ä): 143-8
PMID26593723
show ga
Although fibrosis is an essential response to acute cardiac tissue injury,
prolonged myofibroblast activation and progressive fibrosis lead to further
distortion of tissue architecture and worsened cardiac function. Thus, optimal
tissue repair following injury requires tight control over myofibroblast
activation. It is now recognized that inflammation plays a critical role in
regulating fibrosis. In this review we will highlight how advances in the field
of innate immunity have led to a better understanding of the role of inflammation
in cardiovascular disease and, in particular, in the regulation of fibrosis.
Specifically, we will discuss how the innate immune system recognizes tissue
damage in settings of acute injury and chronic cardiovascular disease. We will
also review the role of different cell populations in this response, particularly
the unique role of different macrophage subsets and mast cells.
free
free
free
