Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25325982
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25325982
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Methods+Mol+Biol
2015 ; 1229
(ä): 567-85
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Role of glycosaminoglycans in infectious disease
#MMPMID25325982
Jinno A
; Park PW
Methods Mol Biol
2015[]; 1229
(ä): 567-85
PMID25325982
show ga
Glycosaminoglycans (GAGs) have been shown to bind to a wide variety of microbial
pathogens, including viruses, bacteria, parasites, and fungi in vitro. GAGs are
thought to promote pathogenesis by facilitating pathogen attachment, invasion, or
evasion of host defense mechanisms. However, the role of GAGs in infectious
disease has not been extensively studied in vivo and therefore their
pathophysiological significance and functions are largely unknown. Here we
describe methods to directly investigate the role of GAGs in infections in vivo
using mouse models of bacterial lung and corneal infection. The overall
experimental strategy is to establish the importance and specificity of GAGs,
define the essential structural features of GAGs, and identify a biological
activity of GAGs that promotes pathogenesis.
free
free
free
