Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29113148
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncol+Lett
2017 ; 14
(5
): 5077-5084
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Role of galectins in lung cancer
#MMPMID29113148
Chang WA
; Tsai MJ
; Kuo PL
; Hung JY
Oncol Lett
2017[Nov]; 14
(5
): 5077-5084
PMID29113148
show ga
Lung cancer is the leading cause of cancer-associated mortality worldwide and is
also associated with a poor prognosis. As in numerous other types of cancer,
galectins have been demonstrated to be involved in the progression of lung
cancer. Galectins belong to a superfamily of lectins, which are
carbohydrate-binding proteins. There are at least 15 members in the galectin
family, however, only galectin-1, -2, -3, -4, -7, -8, -9, -10, -12, and -13 are
found in humans. Galectins are able to mediate interactions between cells,
including homotypic and heterotypic interactions; they also facilitate the
bindings between cells and extracellular matrix components. These cell-cell and
cell-matrix interactions, as well as the galectin signaling on the cell surface,
are able to modulate signaling pathways and thereby influence cellular functions
and behaviors. Galectin-1, -3, -4, -7, -8 and -9 are associated with lung cancer.
These galectins are associated with tumor invasion, migration, metastasis and
progression, and may serve important roles in the tumor microenvironment of lung
cancer. The majority of galectins are associated with the progression of lung
cancer, with the exception of galectin-9, which is associated with enhanced
anticancer immunity. Therefore, galectins may be potential targets for developing
novel lung cancer therapies.
free
free
free
