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Role of extracellular and intracellular microRNAs in sepsis
#MMPMID25086335
Essandoh K
; Fan GC
Biochim Biophys Acta
2014[Nov]; 1842
(11
): 2155-2162
PMID25086335
show ga
Sepsis is the major cause of death in the intensive care unit (ICU). Numerous
biomarkers have been studied to identify the cause and severity of sepsis but
these factors cannot differentiate between infectious and non-infectious
inflammatory response. MicroRNAs (miRNAs) are non-coding RNA transcripts that
regulate the expression of genes by repressing translation or degrading mRNA.
Importantly, miRNAs can be released outside cells and easily detectable in bodily
fluids such as blood, sweat, urine and breast milk. Numerous studies have
explored the idea of utilizing extracellular miRNAs as biomarkers for sepsis by
profiling the dysregulation of miRNAs in blood samples of sepsis patients. So
far, miR-223, miR-146a and miR-150 have been identified to have promising
prognostic and diagnostic value to sepsis. In addition, various intracellular
miRNAs have been implicated to play critical roles in regulating the TLR-NF-?B
pathway, which is a well-known inflammatory signaling pathway involved in the
process of sepsis. Here, we summarize the recent progress on the role of
extracellular and intracellular miRNAs in sepsis. Specifically, we discuss the
possible role of circulating miRNA biomarkers for the diagnosis of sepsis and how
intracellular miRNAs regulate the inflammatory responses in sepsis.
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