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2014 ; 306
(12
): C1101-5
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Role of epigenetics in pulmonary hypertension
#MMPMID24717578
Saco TV
; Parthasarathy PT
; Cho Y
; Lockey RF
; Kolliputi N
Am J Physiol Cell Physiol
2014[Jun]; 306
(12
): C1101-5
PMID24717578
show ga
A significant amount of research has been conducted to examine the pathologic
processes and epigenetic mechanisms contributing to peripheral hypertension.
However, few studies have been carried out to understand the vascular remodeling
behind pulmonary hypertension (PH), including peripheral artery muscularization,
medial hypertrophy and neointima formation in proximal arteries, and plexiform
lesion formation. Similarly, research examining some of the epigenetic principles
that may contribute to this vascular remodeling, such as DNA methylation and
histone modification, is minimal. The understanding of these principles may be
the key to developing new and more effective treatments for PH. The purpose of
this review is to summarize epigenetic research conducted in the field of
hypertension that could possibly be used to understand the epigenetics of PH.
Possible future therapies that could be pursued using information from these
studies include selective histone deacetylase inhibitors and targeted DNA
methyltransferases. Both of these could potentially be used to silence
proproliferative or antiapoptotic genes that lead to decreased smooth muscle cell
proliferation. Epigenetics may provide a glimmer of hope for the eventual
improved treatment of this highly morbid and debilitating disease.
|Apoptosis/drug effects
[MESH]
|Cell Proliferation/drug effects
[MESH]
|DNA Methylation/*genetics
[MESH]
|Epigenesis, Genetic/*genetics
[MESH]
|Histone Deacetylase Inhibitors/therapeutic use
[MESH]
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