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2014 ; 2014
(ä): 596824
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Role of autoimmune responses in periodontal disease
#MMPMID24963400
Nair S
; Faizuddin M
; Dharmapalan J
Autoimmune Dis
2014[]; 2014
(ä): 596824
PMID24963400
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Periodontal diseases are characterized by localized infections and inflammatory
conditions that directly affect teeth supporting structures which are the major
cause of tooth loss. Several studies have demonstrated the involvement of
autoimmune responses in periodontal disease. Evidences of involvement of
immunopathology have been reported in periodontal disease. Bacteria in the dental
plaque induce antibody formation. Autoreactive T cells, natural killer cells,
ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to
have an important role in the autoimmune component of periodontal disease. The
present review describes the involvement of autoimmune responses in periodontal
diseases and also the mechanisms underlying these responses. This review is an
attempt to throw light on the etiopathogenesis of periodontal disease
highlighting the autoimmunity aspect of the etiopathogenesis involved in the
initiation and progression of the disease. However, further clinical trials are
required to strengthen the role of autoimmunity as a cause of periodontal
disease.
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