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2015 ; 10
(4
): 1947-1952
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Role of annexin A6 in cancer
#MMPMID26622779
Qi H
; Liu S
; Guo C
; Wang J
; Greenaway FT
; Sun MZ
Oncol Lett
2015[Oct]; 10
(4
): 1947-1952
PMID26622779
show ga
Annexin A6 (AnxA6) is a member of a conserved superfamily of Ca(2+)-dependent
membrane-binding annexin proteins. It participates in membrane and cytoskeleton
organization, cholesterol homeostasis, membrane trafficking, cell adhesion and
signal transduction. The expression levels of AnxA6 are closely associated with
melanoma, cervical cancer, epithelial carcinoma, breast cancer, gastric cancer,
prostate cancer, acute lymphoblastic leukemia, chronic myeloid leukemia,
large-cell lymphoma and myeloma. AnxA6 exhibits dual functions in cancer, acting
either as a tumor suppressor or promoter, depending on the type of cancer and the
degree of malignancy. In several types of cancer, AnxA6 acts via Ras, Ras/MAPK
and/or FAK/PI3K signaling pathways by mainly mediating PKC?, p120GAP, Bcr-Abl and
YY1. In the present review, the roles of AnxA6 in different types of cancer are
summarized.