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2017 ; 7
(2
): 173-186
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Role of Notch signaling pathway in pancreatic cancer
#MMPMID28337369
Gao J
; Long B
; Wang Z
Am J Cancer Res
2017[]; 7
(2
): 173-186
PMID28337369
show ga
Pancreatic cancer (PC) is one of the highly aggressive malignancies in the United
States. It has been shown that multiple signaling pathways are involved in the
pathogenesis of PC, such as JNK, PI3K/AKT, Rho GTPase, Hedgehog (Hh) and Skp2. In
recent years, accumulated evidence has demonstrated that Notch signaling pathway
plays critical roles in the development and progression of PC. Therefore, in this
review we discuss the recent literature regarding the function and regulation of
Notch in the pathogenesis of PC. Moreover, we describe that Notch signaling
pathway could be down-regulated by its inhibitors or natural compounds, which
could be a novel approach for the treatment of PC patients.