Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26239560
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Role of Neuropilin-1 in Diabetic Nephropathy
#MMPMID26239560
Bondeva T
; Wolf G
J Clin Med
2015[Jun]; 4
(6
): 1293-311
PMID26239560
show ga
Diabetic nephropathy (DN) often develops in patients suffering from type 1 or
type 2 diabetes mellitus. DN is characterized by renal injury resulting in
proteinuria. Neuropilin-1 (NRP-1) is a single-pass transmembrane receptor protein
devoid of enzymatic activity. Its large extracellular tail is structured in
several domains, thereby allowing the molecule to interact with multiple ligands
linking NRP-1 to different pathways through its signaling co-receptors. NRP-1's
role in nervous system development, immunity, and more recently in cancer, has
been extensively investigated. Although its relation to regulation of apoptosis
and cytoskeleton organization of glomerular vascular endothelial cells was
reported, its function in diabetes mellitus and the development of DN is less
clear. Several lines of evidence demonstrate a reduced NRP-1 expression in
glycated-BSA cultured differentiated podocytes as well as in glomeruli from db/db
mice (a model of type 2 Diabetes) and in diabetic patients diagnosed with DN. In
vitro studies of podocytes implicated NRP-1 in the regulation of podocytes'
adhesion to extracellular matrix proteins, cytoskeleton reorganization, and
apoptosis via not completely understood mechanisms. However, the exact role of
NRP-1 during the onset of DN is not yet understood. This review intends to shed
more light on NRP-1 and to present a link between NRP-1 and its signaling
complexes in the development of DN.
free
free
free
