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2015 ; 4
(8
): 1566-77
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Role of MicroRNAs-221/222 in Digestive Systems
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Matsuzaki J
; Suzuki H
J Clin Med
2015[Aug]; 4
(8
): 1566-77
PMID26258795
show ga
MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are
frequently upregulated in several types of human tumors, such as esophageal
adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular
carcinoma, and pancreatic ductal adenocarcinoma. In these cancers, silencing
miR-221/222 could represent a novel anti-tumor approach to inhibit tumor growth
and metastasis. On the other hand, miR-221/222 also play onco-suppressive roles
in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs). Here we will
review the roles of miR-221/222 in digestive systems and their possibility as
prognostic and therapeutic tools.