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2017 ; 8
(4
): ä Nephropedia Template TP
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Role of MYC in B Cell Lymphomagenesis
#MMPMID28375188
Kora? P
; Dotli? S
; Matuli? M
; Zajc Petranovi? M
; Dominis M
Genes (Basel)
2017[Apr]; 8
(4
): ä PMID28375188
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B cell lymphomas mainly arise from different developmental stages of B cells in
germinal centers of secondary lymphoid tissue. There are a number of signaling
pathways that affect the initiation and development of B cell lymphomagenesis.
The functions of several key proteins that represent branching points of
signaling networks are changed because of their aberrant expression, degradation,
and/or accumulation, and those events determine the fate of the affected B cells.
One of the most influential transcription factors, commonly associated with
unfavorable prognosis for patients with B cell lymphoma, is nuclear
phosphoprotein MYC. During B cell lymphomagenesis, oncogenic MYC variant is
deregulated through various mechanisms, such as gene translocation, gene
amplification, and epigenetic deregulation of its expression. Owing to
alterations of downstream signaling cascades, MYC-overexpressing neoplastic B
cells proliferate rapidly, avoid apoptosis, and become unresponsive to most
conventional treatments. This review will summarize the roles of MYC in B cell
development and oncogenesis, as well as its significance for current B cell
lymphoma classification. We compared communication networks within transformed B
cells in different lymphomas affected by overexpressed MYC and conducted a
meta-analysis concerning the association of MYC with tumor prognosis in different
patient populations.
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