Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25394532
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cancer+Metastasis+Rev
2014 ; 33
(4
): 921-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Role of MTA2 in human cancer
#MMPMID25394532
Covington KR
; Fuqua SA
Cancer Metastasis Rev
2014[Dec]; 33
(4
): 921-8
PMID25394532
show ga
Metastasis is the ultimate cause of death for most cancer patients. While many
mechanisms have been delineated for regulation of growth and tumor initiation of
the primary tumor, very little is known about the process of metastasis.
Metastasis requires dynamic alteration of cellular processes in order for cells
to disseminate from the primary tumor to distant sites. These alterations often
involve dramatic changes in the regulation of cytoskeletal and cell-environment
interactions. Furthermore, controlled refinement of these interactions requires
feedback to regulatory networks in the nucleus. MTA2 is a member of the
metastasis tumor-associated family of transcriptional regulators and is a central
component of the nucleosome remodeling and histone deacetylation complex. MTA2
acts as a central hub for cytoskeletal organization and transcription and
provides a link between nuclear and cytoskeletal organization. We will focus on
MTA2 in this chapter, especially its role in breast cancer metastasis.