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2016 ; 20
(5
): 246-58
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Role of Epigenetics in Biology and Human Diseases
#MMPMID27377127
Moosavi A
; Motevalizadeh Ardekani A
Iran Biomed J
2016[Nov]; 20
(5
): 246-58
PMID27377127
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For a long time, scientists have tried to describe disorders just by genetic or
environmental factors. However, the role of epigenetics in human diseases has
been considered from a half of century ago. In the last decade, this subject has
attracted many interests, especially in complicated disorders such as behavior
plasticity, memory, cancer, autoimmune disease, and addiction as well as
neurodegenerative and psychological disorders. This review first explains the
history and classification of epigenetic modifications, and then the role of
epigenetic in biology and connection between the epigenetics and environment are
explained. Furthermore, the role of epigenetics in human diseases is considered
by focusing on some diseases with some complicated features, and at the end, we
have given the future perspective of this field. The present review article
provides concepts with some examples to reveal a broad view of different aspects
of epigenetics in biology and human diseases.
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