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2016 ; 129
(3
): 326-31
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Role of Circulating Fibrocytes in Cardiac Fibrosis
#MMPMID26831236
Lin RJ
; Su ZZ
; Liang SM
; Chen YY
; Shu XR
; Nie RQ
; Wang JF
; Xie SL
Chin Med J (Engl)
2016[Feb]; 129
(3
): 326-31
PMID26831236
show ga
OBJECTIVE: It is revealed that circulating fibrocytes are elevated in
patients/animals with cardiac fibrosis, and this review aims to provide an
introduction to circulating fibrocytes and their role in cardiac fibrosis. DATA
SOURCES: This review is based on the data from 1994 to present obtained from
PubMed. The search terms were "circulating fibrocytes " and "cardiac fibrosis ".
STUDY SELECTION: Articles and critical reviews, which are related to circulating
fibrocytes and cardiac fibrosis, were selected. RESULTS: Circulating fibrocytes,
which are derived from hematopoietic stem cells, represent a subset of peripheral
blood mononuclear cells exhibiting mixed morphological and molecular
characteristics of hematopoietic and mesenchymal cells (CD34+/CD45+/collagen I+).
They can produce extracellular matrix and many cytokines. It is shown that
circulating fibrocytes participate in many fibrotic diseases, including cardiac
fibrosis. Evidence accumulated in recent years shows that aging individuals and
patients with hypertension, heart failure, coronary heart disease, and atrial
fibrillation have more circulating fibrocytes in peripheral blood and/or heart
tissue, and this elevation of circulating fibrocytes is correlated with the
degree of fibrosis in the hearts. CONCLUSIONS: Circulating fibrocytes are
effector cells in cardiac fibrosis.