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2018 ; 13
(ä): 12
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Role of BK human polyomavirus in cancer
#MMPMID29632550
Levican J
; Acevedo M
; León O
; Gaggero A
; Aguayo F
Infect Agent Cancer
2018[]; 13
(ä): 12
PMID29632550
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Human polyomaviruses (HPyV), which are small DNA viruses classified into the
polyomaviridae family, are widely distributed in human populations. Thirteen
distinct HPyVs have been described to date. Some of these viruses have been found
in human tumors, suggesting an etiological relationship with cancer. In
particular, convincing evidence of an oncogenic role has emerged for a specific
HPyV, the Merkel cell polyomavirus (MCPyV). This HPyV has been linked to rare
skin cancer, Merkel cell carcinoma (MCC). This finding may be just the tip of the
iceberg, as HPyV infections are ubiquitous in humans. Many authors have
conjectured that additional associations between HPyV infections and neoplastic
diseases will likely be discovered. In 2012, the International Agency for
Research on Cancer (IARC) evaluated the carcinogenicity of the BK virus (BKPyV),
reporting that BKPyV is "possibly carcinogenic to humans." This review explores
the BKPyV infection from a historical point of view, including biological aspects
related to viral entry, tropism, epidemiology and mechanisms potentially involved
in BKPyV-mediated human carcinogenesis. In order to clarify the role of this
virus in human cancer, more epidemiological and basic research is strongly
warranted.
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