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10.1038/srep13708 http://scihub22266oqcxt.onion/10.1038/srep13708 C4571649!4571649 !26374193     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26374193 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26374193 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 13708 Nephropedia Template TP {{tp|p=26374193 |t=2015. Robust bioengineered 3D functional human intestinal epithelium |pdf=|usr=}}{{26374193 }} gab.com Text Robust bioengineered 3D functional human intestinal epithelium JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26374193 #FOAvip Intestinal functions are central to human physiology, health and disease. Options to study these functions with direct relevance to the human condition remain severely limited when using conventional cell cultures, microfluidic systems, organoids, animal surrogates or human studies. To replicate in vitro the tissue architecture and microenvironments of native intestine, we developed a 3D porous protein scaffolding system, containing a geometrically-engineered hollow lumen, with adaptability to both large and small intestines. These intestinal tissues demonstrated representative human responses by permitting continuous accumulation of mucous secretions on the epithelial surface, establishing low oxygen tension in the lumen, and interacting with gut-colonizing bacteria. The newly developed 3D intestine model enabled months-long sustained access to these intestinal functions in vitro, readily integrable with a multitude of different organ mimics and will therefore ensure a reliable ex vivo tissue system for studies in a broad context of human intestinal diseases and treatments. Twit Text FOAVip Robust bioengineered 3D functional human intestinal epithelium ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26374193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26374193 #FOAvip English Wikipedia <ref>{{Cite pmid|26374193 }}</ref> Robust bioengineered 3D functional human intestinal epithelium #MMPMID26374193 Chen Y ; Lin Y ; Davis KM ; Wang Q ; Rnjak-Kovacina J ; Li C ; Isberg RR ; Kumamoto CA ; Mecsas J ; Kaplan DL Sci Rep 2015[Sep]; 5 (ä): 13708 PMID26374193 show ga Intestinal functions are central to human physiology, health and disease. Options to study these functions with direct relevance to the human condition remain severely limited when using conventional cell cultures, microfluidic systems, organoids, animal surrogates or human studies. To replicate in vitro the tissue architecture and microenvironments of native intestine, we developed a 3D porous protein scaffolding system, containing a geometrically-engineered hollow lumen, with adaptability to both large and small intestines. These intestinal tissues demonstrated representative human responses by permitting continuous accumulation of mucous secretions on the epithelial surface, establishing low oxygen tension in the lumen, and interacting with gut-colonizing bacteria. The newly developed 3D intestine model enabled months-long sustained access to these intestinal functions in vitro, readily integrable with a multitude of different organ mimics and will therefore ensure a reliable ex vivo tissue system for studies in a broad context of human intestinal diseases and treatments. |*Intestinal Mucosa/metabolism [MESH] |*Organoids [MESH] |*Tissue Engineering [MESH] |Animals [MESH] |Biosensing Techniques [MESH] |Cell Line [MESH] |Epithelial Cells/metabolism [MESH] |Humans [MESH] |Insect Proteins [MESH] |Oxygen/metabolism [MESH] |Silk [MESH] |Tissue Culture Techniques [MESH]Robust bioengineered 3D functional human intestinal epithelium (epmc).pdf DeepDyve Pubget Overpricing