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2016 ; 17
(3
): 261-6
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Risk factors for distant metastasis of dermatofibrosarcoma protuberans
#MMPMID27289468
Hayakawa K
; Matsumoto S
; Ae K
; Tanizawa T
; Gokita T
; Funauchi Y
; Motoi N
J Orthop Traumatol
2016[Sep]; 17
(3
): 261-6
PMID27289468
show ga
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely
metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans
(FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP).
Since DFSP rarely metastasizes, there have been few reports summarizing data on
distant metastasis cases at single institution. The aim of this retrospective
study is to review DFSP cases in order to analyze risk factors for metastasis.
PATIENTS AND METHODS: This retrospective study involved 67 patients. We analyzed
O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the
relationship between frequency of local recurrence and metastasis, and the
relationship between primary tumor size and metastasis. RESULTS: Distant
metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the
histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out
of five cases with metastasis, three had not recurred and two had recurred twice.
No clear correlation was identified (Fisher's exact test: p = 0.216). The primary
tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm,
respectively. The tumor diameters in metastatic cases were significantly larger
(Fisher's exact test: p < 0.0001). CONCLUSIONS: In this study, we identified a
stronger correlation between DFSP metastasis and tumor size. There was a high
possibility that the cases with large tumors might be FS-DFSP, having high rate
of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before
primary tumor growth and wide resection is considered important.
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