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2015 ; 38
(1
): 20-4
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Risk assessment of drug-induced QT prolongation
#MMPMID26648606
Isbister GK
Aust Prescr
2015[Feb]; 38
(1
): 20-4
PMID26648606
show ga
Drugs can cause prolongation of the QT interval, alone or in combination,
potentially leading to fatal arrhythmias such as torsades de pointes. When
prescribing drugs that prolong the QT interval, the balance of benefit versus
harm should always be considered. Readouts from automated ECG machines are
unreliable. The QT interval should be measured manually. Changes in heart rate
influence the absolute QT interval. Heart rate correction formulae are
inaccurate, particularly for fast and slow heart rates. The QT nomogram, a plot
of QT interval versus heart rate, can be used as a risk assessment tool to detect
an abnormal QT interval.