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10.1126/science.aaa1193 http://scihub22266oqcxt.onion/10.1126/science.aaa1193 C4501431!4501431 !25838379     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25838379 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25838379 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2015 ; 348 (6230 ): 95-98 Nephropedia Template TP {{tp|p=25838379 |t=2015. Ribosome The structure of the human mitochondrial ribosome |pdf=|usr=}}{{25838379 }} gab.com Text Ribosome The structure of the human mitochondrial ribosome JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25838379 #FOAvip The highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13 essential proteins of oxidative phosphorylation complexes. We have determined the structure of the intact mitoribosome to 3.5 angstrom resolution by means of single-particle electron cryogenic microscopy. It reveals 80 extensively interconnected proteins, 36 of which are specific to mitochondria, and three ribosomal RNA molecules. The head domain of the small subunit, particularly the messenger (mRNA) channel, is highly remodeled. Many intersubunit bridges are specific to the mitoribosome, which adopts conformations involving ratcheting or rolling of the small subunit that are distinct from those seen in bacteria or eukaryotes. An intrinsic guanosine triphosphatase mediates a contact between the head and central protuberance. The structure provides a reference for analysis of mutations that cause severe pathologies and for future drug design. Twit Text FOAVip Ribosome The structure of the human mitochondrial ribosome ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25838379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25838379 #FOAvip English Wikipedia <ref>{{Cite pmid|25838379 }}</ref> Ribosome The structure of the human mitochondrial ribosome #MMPMID25838379 Amunts A ; Brown A ; Toots J ; Scheres SHW ; Ramakrishnan V Science 2015[Apr]; 348 (6230 ): 95-98 PMID25838379 show ga The highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13 essential proteins of oxidative phosphorylation complexes. We have determined the structure of the intact mitoribosome to 3.5 angstrom resolution by means of single-particle electron cryogenic microscopy. It reveals 80 extensively interconnected proteins, 36 of which are specific to mitochondria, and three ribosomal RNA molecules. The head domain of the small subunit, particularly the messenger (mRNA) channel, is highly remodeled. Many intersubunit bridges are specific to the mitoribosome, which adopts conformations involving ratcheting or rolling of the small subunit that are distinct from those seen in bacteria or eukaryotes. An intrinsic guanosine triphosphatase mediates a contact between the head and central protuberance. The structure provides a reference for analysis of mutations that cause severe pathologies and for future drug design. |Aminoglycosides/pharmacology/therapeutic use [MESH] |Anti-Bacterial Agents/pharmacology [MESH] |Crystallography, X-Ray [MESH] |Drug Resistance, Bacterial/genetics [MESH] |GTP Phosphohydrolases/chemistry [MESH] |Genetic Diseases, Inborn/drug therapy/genetics [MESH] |Humans [MESH] |Mitochondria/chemistry/*ultrastructure [MESH] |RNA, Messenger/chemistry [MESH] |RNA, Ribosomal/chemistry [MESH] |Ribosomal Proteins/chemistry [MESH]Ribosome The structure of the human mitochondrial ribosome (epmc).pdf DeepDyve Pubget Overpricing