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2015 ; 50
(3
): 181-93
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Ribonucleotides in bacterial DNA
#MMPMID25387798
Schroeder JW
; Randall JR
; Matthews LA
; Simmons LA
Crit Rev Biochem Mol Biol
2015[]; 50
(3
): 181-93
PMID25387798
show ga
In all living cells, DNA is the storage medium for genetic information. Being
quite stable, DNA is well-suited for its role in storage and propagation of
information, but RNA is also covalently included in DNA through various
mechanisms. Recent studies also demonstrate useful aspects of including
ribonucleotides in the genome during repair. Therefore, our understanding of the
consequences of RNA inclusion into bacterial genomic DNA is just beginning, but
with its high frequency of occurrence the consequences and potential benefits are
likely to be numerous and diverse. In this review, we discuss the processes that
cause ribonucleotide inclusion in genomic DNA, the pathways important for
ribonucleotide removal and the consequences that arise should ribonucleotides
remain nested in genomic DNA.