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2015 ; 209
(2
): 199-210
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Review series: The cell biology of renal filtration
#MMPMID25918223
Scott RP
; Quaggin SE
J Cell Biol
2015[Apr]; 209
(2
): 199-210
PMID25918223
show ga
The function of the kidney, filtering blood and concentrating metabolic waste
into urine, takes place in an intricate and functionally elegant structure called
the renal glomerulus. Normal glomerular function retains circulating cells and
valuable macromolecular components of plasma in blood, resulting in urine with
just trace amounts of proteins. Endothelial cells of glomerular capillaries, the
podocytes wrapped around them, and the fused extracellular matrix these cells
form altogether comprise the glomerular filtration barrier, a dynamic and highly
selective filter that sieves on the basis of molecular size and electrical
charge. Current understanding of the structural organization and the cellular and
molecular basis of renal filtration draws from studies of human glomerular
diseases and animal models of glomerular dysfunction.