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2017 ; 7
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Review of SERS Substrates for Chemical Sensing
#MMPMID28594385
Mosier-Boss PA
Nanomaterials (Basel)
2017[Jun]; 7
(6
): ä PMID28594385
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The SERS effect was initially discovered in the 1970s. Early research focused on
understanding the phenomenon and increasing enhancement to achieve single
molecule detection. From the mid-1980s to early 1990s, research started to move
away from obtaining a fundamental understanding of the phenomenon to the
exploration of analytical applications. At the same time, significant
developments occurred in the field of photonics that led to the advent of
inexpensive, robust, compact, field-deployable Raman systems. The 1990s also saw
rapid development in nanoscience. This convergence of technologies (photonics and
nanoscience) has led to accelerated development of SERS substrates to detect a
wide range of chemical and biological analytes. It would be a monumental task to
discuss all the different kinds of SERS substrates that have been explored.
Likewise, it would be impossible to discuss the use of SERS for both chemical and
biological detection. Instead, a review of the most common metallic (Ag, Cu, and
Au) SERS substrates for chemical detection only is discussed, as well as SERS
substrates that are commercially available. Other issues with SERS for chemical
detection have been selectivity, reversibility, and reusability of the
substrates. How these issues have been addressed is also discussed in this
review.