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10.1038/nrm.2016.121 http://scihub22266oqcxt.onion/10.1038/nrm.2016.121 C5198518!5198518 !27703243     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27703243 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Mol+Cell+Biol 2017 ; 18 (1 ): 5-17 Nephropedia Template TP {{tp|p=27703243 |t=2017. Reverse-topology membrane scission by the ESCRT proteins |pdf=|usr=}}{{27703243 }} gab.com Text Reverse-topology membrane scission by the ESCRT proteins JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27703243 #FOAvip The narrow membrane necks formed during viral, exosomal and intra-endosomal budding from membranes, as well as during cytokinesis and related processes, have interiors that are contiguous with the cytosol. Severing these necks involves action from the opposite face of the membrane as occurs during the well-characterized formation of coated vesicles. This 'reverse' (or 'inverse')-topology membrane scission is carried out by the endosomal sorting complex required for transport (ESCRT) proteins, which form filaments, flat spirals, tubes and conical funnels that are thought to direct membrane remodelling and scission. Their assembly, and their disassembly by the ATPase vacuolar protein sorting-associated 4 (VPS4) have been intensively studied, but the mechanism of scission has been elusive. New insights from cryo-electron microscopy and various types of spectroscopy may finally be close to rectifying this situation. Twit Text FOAVip Reverse-topology membrane scission by the ESCRT proteins ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27703243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27703243 #FOAvip English Wikipedia <ref>{{Cite pmid|27703243 }}</ref> Reverse-topology membrane scission by the ESCRT proteins #MMPMID27703243 Schöneberg J ; Lee IH ; Iwasa JH ; Hurley JH Nat Rev Mol Cell Biol 2017[Jan]; 18 (1 ): 5-17 PMID27703243 show ga The narrow membrane necks formed during viral, exosomal and intra-endosomal budding from membranes, as well as during cytokinesis and related processes, have interiors that are contiguous with the cytosol. Severing these necks involves action from the opposite face of the membrane as occurs during the well-characterized formation of coated vesicles. This 'reverse' (or 'inverse')-topology membrane scission is carried out by the endosomal sorting complex required for transport (ESCRT) proteins, which form filaments, flat spirals, tubes and conical funnels that are thought to direct membrane remodelling and scission. Their assembly, and their disassembly by the ATPase vacuolar protein sorting-associated 4 (VPS4) have been intensively studied, but the mechanism of scission has been elusive. New insights from cryo-electron microscopy and various types of spectroscopy may finally be close to rectifying this situation. |ATPases Associated with Diverse Cellular Activities [MESH] |Cell Membrane/metabolism [MESH] |Endosomal Sorting Complexes Required for Transport/*chemistry/*metabolism [MESH] |Endosomes/metabolism [MESH] |HIV-1/metabolism [MESH] |Humans [MESH]Reverse-topology membrane scission by the ESCRT proteins (epmc).pdf DeepDyve Pubget Overpricing