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2017 ; 33
(ä): 319-342
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Rethinking m(6)A Readers, Writers, and Erasers
#MMPMID28759256
Meyer KD
; Jaffrey SR
Annu Rev Cell Dev Biol
2017[Oct]; 33
(ä): 319-342
PMID28759256
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In recent years, m(6)A has emerged as an abundant and dynamically regulated
modification throughout the transcriptome. Recent technological advances have
enabled the transcriptome-wide identification of m(6)A residues, which in turn
has provided important insights into the biology and regulation of this pervasive
regulatory mark. Also central to our current understanding of m(6)A are the
discovery and characterization of m(6)A readers, writers, and erasers. Over the
last few years, studies into the function of these proteins have led to important
discoveries about the regulation and function of m(6)A. However, during this time
our understanding of these proteins has also evolved considerably, sometimes
leading to the reversal of early concepts regarding the reading, writing and
erasing of m(6)A. In this review, we summarize recent advances in m(6)A research,
and we highlight how these new findings have reshaped our understanding of how
m(6)A is regulated in the transcriptome.