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2015 ; 20
(8
): 797-810
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Resveratrol and liver: A systematic review
#MMPMID26664429
Faghihzadeh F
; Hekmatdoost A
; Adibi P
J Res Med Sci
2015[Aug]; 20
(8
): 797-810
PMID26664429
show ga
BACKGROUND: Recent studies demonstrated that resveratrol has many therapeutic
effects on liver disorders. Resveratrol significantly increased survival after
liver transplantation, decreased fat deposition, necrosis, and apoptosis which
induced by ischemia in Wistar rats. It provided liver protection against
chemical, cholestatic, and alcohol injury. Resveratrol can improve glucose
metabolism and lipid profile and decrease liver fibrosis and steatosis.
Furthermore, it was able to alter hepatic cell fatty acid composition. According
to extension of liver disease around the world and necessity of finding new
threat, this review critically examines the current preclinical in vitro and in
vivo studies on the preventive and therapeutic effects of resveratrol in liver
disorders. MATERIALS AND METHODS: A search in PubMed, Google Scholar, and Scopus
was undertaken to identify relevant literature using search terms, including
"liver," "hepatic," and "Resveratrol." Both in vivo and in vitro studies were
included. No time limiting considered for this search. RESULTS: A total of 76
articles were eligible for this review. In these articles, resveratrol shows
antioxidative properties in different models of hepatitis resulting in reducing
of hepatic fibrosis. CONCLUSION: Resveratrol could reduce hepatic steatosis
through modulating the insulin resistance and lipid profile in animals. These
high quality preclinical studies propose the potential therapeutic implication of
resveratrol in liver disorders especially those with hepatic steatosis.
Resveratrol can play a pivotal role in prevention and treatment of liver
disorders by reducing hepatic fibrosis.