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10.1016/j.burns.2014.01.005 http://scihub22266oqcxt.onion/10.1016/j.burns.2014.01.005 C4336194!4336194 !24582755     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24582755 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24582755 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Burns 2014 ; 40 (7 ): 1338-44 Nephropedia Template TP {{tp|p=24582755 |t=2014. Response of human skin to esthetic scarification |pdf=|usr=}}{{24582755 }} gab.com Text Response of human skin to esthetic scarification JO: Burns http://www.kidney.de/pget.php?&tw=1&pmid=24582755 #FOAvip This study was undertaken to investigate changes in RNA expression in previously healthy adult human skin following thermal injury induced by contact with hot metal that was undertaken as part of esthetic scarification, a body modification practice. Subjects were recruited to have pre-injury skin and serial wound biopsies performed. 4 mm punch biopsies were taken prior to branding and 1 h, 1 week, and 1, 2 and 3 months after injury. RNA was extracted and quality assured prior to the use of a whole-genome based bead array platform to describe expression changes in the samples using the pre-injury skin as a comparator. Analysis of the array data was performed using k-means clustering and a hypergeometric probability distribution without replacement and corrections for multiple comparisons were done. Confirmatory q-PCR was performed. Using a k of 10, several clusters of genes were shown to co-cluster together based on Gene Ontology classification with probabilities unlikely to occur by chance alone. OF particular interest were clusters relating to cell cycle, proteinaceous extracellular matrix and keratinization. Given the consistent expression changes at 1 week following injury in the cell cycle cluster, there is an opportunity to intervene early following burn injury to influence scar development. Twit Text FOAVip Response of human skin to esthetic scarification ????Burns http://www.kidney.de/pget.php?&tw=1&pmid=24582755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24582755 #FOAvip English Wikipedia <ref>{{Cite pmid|24582755 }}</ref> Response of human skin to esthetic scarification #MMPMID24582755 Gabriel VA ; McClellan EA ; Scheuermann RH Burns 2014[Nov]; 40 (7 ): 1338-44 PMID24582755 show ga This study was undertaken to investigate changes in RNA expression in previously healthy adult human skin following thermal injury induced by contact with hot metal that was undertaken as part of esthetic scarification, a body modification practice. Subjects were recruited to have pre-injury skin and serial wound biopsies performed. 4 mm punch biopsies were taken prior to branding and 1 h, 1 week, and 1, 2 and 3 months after injury. RNA was extracted and quality assured prior to the use of a whole-genome based bead array platform to describe expression changes in the samples using the pre-injury skin as a comparator. Analysis of the array data was performed using k-means clustering and a hypergeometric probability distribution without replacement and corrections for multiple comparisons were done. Confirmatory q-PCR was performed. Using a k of 10, several clusters of genes were shown to co-cluster together based on Gene Ontology classification with probabilities unlikely to occur by chance alone. OF particular interest were clusters relating to cell cycle, proteinaceous extracellular matrix and keratinization. Given the consistent expression changes at 1 week following injury in the cell cycle cluster, there is an opportunity to intervene early following burn injury to influence scar development. |*Body Modification, Non-Therapeutic [MESH] |Adult [MESH] |Burns/*genetics [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Longitudinal Studies [MESH] |Male [MESH] |Prospective Studies [MESH] |RNA, Messenger/*metabolism [MESH] |Skin/*metabolism [MESH] |Wound Healing/*genetics [MESH]Response of human skin to esthetic scarification (epmc).pdf DeepDyve Pubget Overpricing